Understanding the mechanism of retinal detachment-induced photoreceptor apoptosis: neuroprotective treatments for photoreceptor apoptosis
نویسندگان
چکیده
منابع مشابه
Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis.
Photoreceptor apoptosis is a major cause of visual loss in retinal detachment (RD) and several other visual disorders, but the underlying mechanisms remain elusive. Recently, increased expression of monocyte chemoattractant protein 1 (MCP-1) was reported in vitreous humor samples of patients with RD and diabetic retinopathy as well as in the brain tissues of patients with neurodegenerative dise...
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Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal disorders, causes photoreceptor loss and subsequent vision decline. Although caspase-dependent apoptotic pathways are activated after retinal detachment, caspase inhibition by the pan-caspase inhibitor Z-VAD fails to preven...
متن کاملApoptosis and other cell death mechanisms after retinal detachment: implications for photoreceptor rescue.
Retinal detachment (RD) is one of the most common causes of blindness. This separation of the neurosensory retina from its underlying retinal pigment epithelium results in photoreceptor loss, which is the basis of permanent visual impairment. This review explores the various cell death mechanisms in photoreceptor death associated with RD. One of the major mechanisms is apoptosis, mediated by th...
متن کاملViral delivery of heme oxygenase-1 attenuates photoreceptor apoptosis in an experimental model of retinal detachment
This study was designed to evaluate the efficacy of subretinal injection of recombinant adeno-associated virus vector expressing heme oxygenase-1 (rAAV-HO-1) in attenuating photoreceptor apoptosis induced by experimental retinal detachment (RD) in Sprague-Dawley rats. Our results disclosed that subretinal rAAV-HO-1 delivery achieved localized high HO-1 gene expression in retinal outer nuclear l...
متن کاملApoptotic photoreceptor degeneration in experimental retinal detachment.
PURPOSE To investigate the possibility that cell death in retinal detachment may occur by reactivation of apoptotic programmed cell death mechanisms. METHODS Unilateral retinal detachments were created in adult cats using 0.25% sodium hyaluronate; detached and control retinas were studied at different intervals. Internucleosomal DNA fragmentation (one of the landmarks of apoptosis) was invest...
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ژورنال
عنوان ژورنال: Inflammation and Regeneration
سال: 2008
ISSN: 1880-9693,1880-8190
DOI: 10.2492/inflammregen.28.522